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KMID : 0043319930160010025
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Archives of Pharmacal Research
1993 Volume.16 No. 1 p.25 ~ p.28
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Antiinfammatory Activity of Naturally Occurring Flavone and Flavonol Glycosides
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Lee SJ
Son KH/Chang HW/Do JC/Jung KY/Kang SS/Kim HP
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Abstract
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Our previous report demonstrated that certain flavonoid aglycones such as apigenin (flavone), quercetin, morin (flavonols), and biochanin A (isoflavone) showed in vivo antiinflammatory activity via topical and oral routes of administration. As a continual study, the various flavonoid glycosides have been evaluated in mouse ear edema assay using archidonic acid or crotonoil as a inflammagen. Flavonoids were orally administered (2mg/mouse) and ear edema inhibition was measured. Significant antiinflammatory activities were found especially in flavone and flavonol glycosides (15-29% inhibition) although the flavonoid derivatives tested showed less antiinflammatory activity than hydrocortisone or indomethacin. Chalcone and flavanone derivatives were not significantly active. And in general, flavonol glycosides of kaempferol type were found to have a higher oral antiinflammatory activity than that of flavonol glycosides of quercetin-type in mice.
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